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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, provided they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a clinical trial that enrolled patients without diabetes established that patients had an average weight loss of 4.1% as opposed to participants have been given placebos) within a 12- month period, while a different study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight naturally can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err on the side of caution and allow FDA do its job and demand some investigation be done so that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on his or her medications.

Researchers found out that participants investing in this drug to get a year, dropped a few pounds within four weeks and have kept the body weight off during the entire 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs that are made up of more than one active ingredient, which may make them more potent and safer.

Combo-pilling may be the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there aren't long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure level and pulse rate, and really should not be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

"This could be the first drug I'm aware of that targets the appetite and reward centres within the brain," he said.

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